The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2−/−, but not in cyclooxygenase-1−/− mice

Human cyclooxygenase-2 cDNA.

Timothy Hla, Karen M. Neilson · Proceedings of the National Academy of Sciences · 1992 · 1.5K citations

Life Sciences, Cell Biology, Molecular Biology +12

Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids

Kanato Yamagata, Katrin I. Andreasson, Walter E. Kaufmann et al. · Neuron · 1993 · 1.2K citations

Life Sciences, Neurobiology, Neuroscience +14

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

Robert Langenbach, Scott G. Morham, Howard F. Tiano et al. · Cell · 1995 · 1.1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

Scott G. Morham, Robert Langenbach, Charles D. Loftin et al. · Cell · 1995 · 1.1K citations · Full text

Medicine, Molecular Biology, Molecular Genetics +13

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

Nobuko Futaki, Satoru Takahashi, Motofumi Yokoyama et al. · Prostaglandins · 1994 · 833 citations

Medicine, Medicinal Chemistry, Pharmacology +14