Human hepatocyte cell lines proliferating as cohesive spheroid colonies in alginate markedly upregulate both synthetic and detoxificatory liver function

Fulminant hepatic failure: Summary of a workshop

J H Hoofnagle, Robert L. Carithers, Craig Shapiro et al. · Hepatology · 1995 · 539 citations

Medicine, Internal Medicine, Pathology +15

Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium.

Geoffrey D. Block, Joseph Locker, William C. Bowen et al. · The Journal of Cell Biology · 1996 · 492 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Switching from differentiation to growth in hepatocytes: Control by extracellular matrix

David Mooney, Linda K. Hansen, Joseph P. Vacanti et al. · Journal of Cellular Physiology · 1992 · 460 citations

Life Sciences, Bioengineering, Cell Biology +17

Clinical Experience With a Bioartificial Liver in the Treatment of Severe Liver Failure

F. Watanabe, Claudy Mullon, Winston R. Hewitt et al. · Annals of Surgery · 1997 · 457 citations · Full text

Medicine, Surgery, Hepatology +15

Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments

Norio Koide, Khosaku Sakaguchi, Yayoi Koide et al. · Experimental Cell Research · 1990 · 441 citations

Engineering, Bioengineering, Cell Biology +12