Pathologic Fracture Associated With Amyloid Deposition in the Bone of a Chronic Hemodialysis Patient

Abstract

A 63-year-old male who had been on hemodialysis for 14 years developed extensive amyloid deposition in the femoral head and neck that, after a fall, resulted in a femoral neck fracture. The plasma level of beta 2-microglobulin in this patient was elevated, and bone specimens from the fracture site demonstrated positive Congo-red staining, suggesting an association with amyloid deposition.