PCR-Restriction Fragment Length Polymorphism Can Also Detect Point Mutation A2142C in the 23S rRNA Gene, Associated with <i>Helicobacter pylori</i> Resistance to Clarithromycin

Abstract

Clarithromycin resistance, the major cause of Helicobacter pylori treatment failure ([2][1], [7][2]), is attributed to point mutations within the peptidyltransferase-encoding region in domain V of the 23S rRNA gene ([10][3], [15][4]). Three distinct point mutations have been found to be associated