Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity

Stat3 as an Oncogene

Jacqueline Bromberg, Melissa H Wrzeszczynska, Geeta Devgan et al. · Cell · 1999 · 2.8K citations · Full text

Medicine, Biochemistry, Molecular Biology +8

Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines

Quan Lin, Raymond Lai, Lucian R. Chirieac et al. · American Journal Of Pathology · 2005 · 207 citations · Full text

Life Sciences, Molecular Biology, Oncology +12

JAK1 Activates STAT3 Activity in Non-Small–Cell Lung Cancer Cells and IL-6 Neutralizing Antibodies Can Suppress JAK1-STAT3 Signaling

Lanxi Song, Bhupendra Rawal, Jeffrey A. Nemeth et al. · Molecular Cancer Therapeutics · 2011 · 180 citations · Full text

Medicine, Cancer Biology, Oncology +17

Sorafenib Overcomes TRAIL Resistance of Hepatocellular Carcinoma Cells through the Inhibition of STAT3

Kuen‐Feng Chen, Wei‐Tien Tai, Tsung‐Hao Liu et al. · Clinical Cancer Research · 2010 · 170 citations

Life Sciences, Oncology, Pharmacology +17

Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma

Wei‐Tien Tai, Ann‐Lii Cheng, Chung-Wai Shiau et al. · Journal of Hepatology · 2011 · 157 citations

Life Sciences, Molecular Biology, Oncology +17