Enzymatic conjugation of benzo(a)pyrene oxides, phenols and dihydrodiols with UDP-glucuronic acid

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

Peter Sims, P.L. Grover, Alan Swaisland et al. · Nature · 1974 · 1.1K citations

Life Sciences, Biochemistry, Metabolism +12

Substrate-Induced Synthesis And Other Properties Of Benzpyrene Hydroxylase In Rat Liver

Allan H. Conney, E. C. Miller, J. A. Miller · Journal of Biological Chemistry · 1957 · 472 citations · Full text

Medicine, Biochemistry, Pharmacology +14

AN ENZYME CATALYSING THE CONJUGATION OF EPOXIDES WITH GLUTATHIONE

E. Boyland, K. Williams · Biochemical Journal · 1965 · 188 citations · Full text

Life Sciences, Biochemistry, Enzyme Mechanism +12

High-pressure liquid chromatographic analysis of benzo(alpha)pyrene metabolism and covalent binding and the mechanism of action of 7,8-benzoflavone and 1,2-epoxy-3,3,3-trichloropropane.

James K. Selkirk, Robert G. Croy, Peter P. Roller et al. · PubMed · 1974 · 171 citations

Pharmacy, Pharmacology, Chromatographic Analysis +14

Mutagenicity of non-K-region diols and diol-epoxides of benz(a)anthracene and benzo(a)pyrene in S. typhimurium TA 100

C. Malaveille, Helmut Bartsch, P.L. Grover et al. · Biochemical and Biophysical Research Communications · 1975 · 166 citations

Pharmacy, Chemistry, Toxicology +10