Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Owen P. Hamill, Alain Marty, Erwin Neher et al. · Pflügers Archiv - European Journal of Physiology · 1981 · 18.5K citations

Natural Sciences, Biophysics, Cell Biology +16

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Goodman and Gilman's the Pharmacological Basis of Therapeutics

William H. Stigelman, D Pharm · Military Medicine · 1986 · 6.8K citations

Medicine, Pharmacology, Pharmacotherapy +6

Drugs and the treatment of psychiatric disorders

R. J. Baldessarini · Medical Entomology and Zoology · 1996 · 688 citations

Pharmacy, Pharmacotherapy, Psychiatry +12

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

Bert Sakmann, Joseph B. Patlak, Erwin Neher · Nature · 1980 · 605 citations

Life Sciences, Neuroscience, Pharmacology +12