Proceedings of the National Academy of Sciences · 1970 · 195 citations · 10 references
Permanent DestructionMammalian PhysiologyNewborn AnimalsPeripheral NerveSympathetic GangliaPeripheral Nervous SystemNeuromuscular BlockadeAdrenal GlandSympathetic Nervous SystemNeurochemistryHealth SciencesNeuropharmacologyNervous SystemPharmacologyNeurophysiologyNeuroanatomyPhysiologyNeuroscienceCentral Nervous SystemMedicineNewborn Mammals
A selective and permanent destruction of sympathetic ganglia was achieved by injecting 6-hydroxydopamine in newborn animals. A lifelong chemical sympathectomy may thus be obtained. The process of cell damage and destruction is substantially different from that produced with an antiserum to a specific nerve growth factor.
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