Solid-Phase Synthesis of Some Alkyl Hydrogen Methylphosphonates

Abstract

Eleven alkyl hydrogen methylphosphonates of structure RO(HO) P(O)Me were made by phosphoramidite chemistry on hydroxymethyl polystyrene resin; R = Me, Et, n -Pr, i -Pr, n -Bu, n -hexyl, n -octyl, cyclohexyl, cycloheptyl, cyclooctyl, and 3,3-dimethylbutan-2-yl ie. pinacolyl or Me 3 C--CH(Me)--.