Concepedia

Cyclometalated iridium(iii)–β-carboline complexes as potent autophagy-inducing agents

Liang He, Siyan Liao, Cai‐Ping Tan, Yiying Lu, Cuixia Xu, Liang‐Nian Ji, Zong‐Wan Mao

Chemical Communications · 2014 · 67 citations · 23 references

DOI

Abstract

Two cyclometalated Ir(III)-β-carboline complexes were identified as potent inducers of autophagic cell death. Autophagy induced by these complexes is ROS-mediated and caspase-independent.

References

23

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Ruth Scherz‐Shouval, Elena Shvets, Ephraim Fass et al. · The EMBO Journal · 2007 · 2.1K citations · Full text

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3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

Per O. Seglen, Paul B. Gordon · Proceedings of the National Academy of Sciences · 1982 · 1.3K citations · Full text

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Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism

Xiaolin Wan, B Harkavy, Patrick J. Grohar et al. · Oncogene · 2006 · 745 citations

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Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

María Salazar‐Roa, Arkaitz Carracedo, Íñigo J. Salanueva et al. · Journal of Clinical Investigation · 2009 · 676 citations · Full text

Induction of autophagic cell death in malignant glioma cells by arsenic trioxide.

Takao Kanzawa, Yasuko Kondo, Hideaki Ito et al. · PubMed · 2003 · 550 citations

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