Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats

Protein kinase Cα activates RAF-1 by direct phosphorylation

Walter Kölch, Gisela Heidecker, Georg Kochs et al. · Nature · 1993 · 1.3K citations

Life Sciences, Cell Biology, Molecular Biology +11

Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

Dorothee C. Schönwaßer, Richard Marais, Christopher J. Marshall et al. · Molecular and Cellular Biology · 1998 · 760 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

Toyoshi Inoguchi, Ruggero Battan, Eugene S. Handler et al. · Proceedings of the National Academy of Sciences · 1992 · 740 citations

Life Sciences, Biochemistry, Endocrinology +14

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

Daisuke Koya, M.R. Jirousek, Y W Lin et al. · Journal of Clinical Investigation · 1997 · 537 citations · Full text

Medicine, Cell Biology, Pharmacology +16

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

Pu Xia, Toyoshi Inoguchi, Timothy S. Kern et al. · Diabetes · 1994 · 456 citations

Life Sciences, Biochemistry, Endocrinology +14