Cell‐Free HIV‐1 Virucidal Action by Modified Peptide Triazole Inhibitors of Env gp120

Abstract

Virus interrupted! Initial entry of HIV-1 into host cells remains a compelling and yet elusive target for developing agents to prevent infection. Here, we report the ability of modified, site- specific peptide triazole inhibitors that target HIV-1 gp120 to physically disrupt virus particles in the absence of host cells.