Journal of Andrology · 2008 · 31 citations · 42 references
SpermatogenesisGenetic TestingFertilityCytogeneticsGeneticsGenetic EpidemiologyReproductive HealthGynecologySemen AnalysisReproductive BiologyFertilisationInfertile Mexican MenY Chromosome DeletionsMexican MenSex DifferencesMale InfertilityPublic HealthInfertilityAndrologyHuman ReproductionUrologyGenetic DisorderY Chromosome MicrodeletionsGenetic ScreeningMedicine
In our study, we analyzed chromosomal abnormalities, Y chromosome deletions, androgen receptor CAG repeat length and their association with defective spermatogenesis in infertile Mexican men. Eighty-two infertile patients and 40 controls were screened for karyotypic abnormalities, Y chromosome microdeletions, and CAG repeats. Nine infertile males (11%) carried chromosomal abnormalities and 10 (12.2%) presented Y chromosome microdeletions. The mean CAG repeat length was 21.6 and 20.88 base pairs in idiopathic infertile males and controls, respectively. Our results suggest that chromosomal aberrations and Y-chromosomal microdeletions are related to male infertility in Mexican men. In addition, expansion of the CAG repeat segments of the androgen receptor is not correlated with male idiopathic infertility.
42
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes
Helen Skaletsky, Tomoko Kuroda-Kawaguchi, Patrick Minx et al. · Nature · 2003 · 2.2K citations