Analytical Chemistry · 1996 · 57 citations · 16 references
Natural SciencesChemistryAnalytical ChemistryMass Spectrometric AnalysisSpectroscopyAerosol ChemistryAerosol ScienceMass AnalyzersMass SpectrometryPeptide AnalysisPeptide IdentificationAerosol Mass SpectrometryMaldi-tof Mass SpectrometryMatrix-assisted Laser Desorption Ionization Time-of-flight Mass SpectrometryMatrix-assisted Laser Desorption/ionizationMatrix-assisted Laser Desorption/ionization Time-of-flight Mass SpectrometryPeptide Mass SpectrometryResolution EnhancementTime-of-flight Mass Spectrometry
Aerosol matrix-assisted laser desorption/ionization (MALDI) has been combined with a reflectron time-of-flight mass spectrometer for improved mass resolution. A methanol solution of matrix and analyte was sprayed directly into a reflectron time-of-flight mass spectrometer, and the aerosol particles were irradiated and ionized with a frequency-tripled Nd:YAG laser at 355 nm. Mass resolution of over 300 was observed for the peptides bradykinin, angiotensin II, and gramicidin D and for vitamin B(12). This represents a resolution enhancement of approximately 10-fold over that previously reported for aerosol MALDI with a linear time-of-flight instrument.
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Brian T. Chait, Rong Wang, Ronald C. Beavis et al. · Science · 1993 · 311 citations
Life Sciences, Biochemistry, Mass Spectrometric Analysis +13
R. Kaufmann, Dieter Kirsch, Bernhard Spengler · International Journal of Mass Spectrometry and Ion Processes · 1994 · 273 citations