TIMP-3 deficiency accelerates cardiac remodeling after myocardial infarction

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

Jan H. Wijsman, R. R. Jonker, R Keijzer et al. · Journal of Histochemistry & Cytochemistry · 1993 · 810 citations · Full text

Life Sciences, Cell Biology, Pathology +13

Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction

Anique Ducharme, Stefan Frantz, Masanori Aikawa et al. · Journal of Clinical Investigation · 2000 · 808 citations · Full text

Medicine, Cardiology, Pathobiology +12

A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2

Jian Qi, Quteba Ebrahem, Nina Z. Moore et al. · Nature Medicine · 2003 · 653 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis.

Andrew H. Baker, A B Zaltsman, Sarah J. George et al. · Journal of Clinical Investigation · 1998 · 466 citations · Full text

Life Sciences, Cell Biology, Apoptosis +11

Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation

Paul W.M. Fedak, Mauro P.L de, Subodh Verma et al. · Journal of Thoracic and Cardiovascular Surgery · 2003 · 438 citations · Full text

Medicine, Cardiology, Surgery +16