A CASE OF OVARIAN AGENESIS WITH NORMAL URINARY GONADOTROPIN TITER

Abstract

THE syndrome of ovarian agenesis has been rather extensively characterized by several authors since Turner's clinical description in 1938 (1–6) We wish to present an unusual case of ovarian agenesis in which we were obliged to confirm the diagnosis by biopsy of the rudimentary ovariananlagen because of a consistently normal urinary gonadotropic hormoneassay and normal development of the breasts and external genitalia. Mrs. T. A., a 35-year-old Greek female, was first seen in the clinic on June 10, 1949, with a chief complaint of sterility after nine years of marriage. She stated that she had never spontaneously menstruated in her” life. Her early developmental history was entirelynormal and she had had no major illnesses, injuries or operations. She was first noted to be unusually short when she ceased growing at about 14 years of age. Review by systems revealed no abnormalities. One brother and one sister were well and both had children. Her mother had had a large goiter; otherwise the family history was negative.