Decrease of tolerance to, and physical dependence on morphine by glutamate receptor antagonists

SYNTHETIC ANALGESICS. II. DITHIENYLBUTENYL- AND DITHIENYLBUTYLAMINES

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Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

Keith A. Trujillo, Huda Akil · Science · 1991 · 1.2K citations

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Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

Linda M. Aanonsen, George L. Wilcox · Journal of Pharmacology and Experimental Therapeutics · 1987 · 375 citations

Medicine, Neuroscience, Pharmacology +17

Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat

Przemysław Marek, Shamgar Ben‐Eliyahu, Michael S. Gold et al. · Brain Research · 1991 · 299 citations

Medicine, Neuroscience, Pharmacology +12

The NMDA Receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids

Kathryn Elliott, Nobuko Minami, Yuri Kolesnikov et al. · Pain · 1994 · 278 citations

Medicine, Pharmacology, Molecular Pharmacology +15