The metabolism of pentachloromethylthiobenzene in germ-free and conventional rats

Abstract

1. Both germfree and conventional rats excreted over 80% of oral doses of pentachloromethylthio[14C]benzene in the faeces.2. The faeces from germ-free rats contained mainly N-acetyl-S-(methylthiotetrachlorophenyl)cysteine.3. The faeces from conventional rats contained bis-(methylthio)tetrachlorobenzene and non-extractable residues in about equal amounts.