Synthesis of 21,21-Difluoro-3β-hydroxy-20-methylpregna-5,20-diene and 5,16,20-Triene as potential inhibitors of steroid C17(20) lyase

Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.

Bon‐chu Chung, J Picado-Leonard, Mitsuru Haniu et al. · Proceedings of the National Academy of Sciences · 1987 · 451 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Characterization of Complementary Deoxyribonucleic Acid for Human Adrenocortical 17α-Hydroxylase: A Probe for Analysis of 17α-Hydroxylase Deficiency*

Karen D. Bradshaw, Michael R. Waterman, Robert T. Couch et al. · Molecular Endocrinology · 1987 · 88 citations · Full text

Life Sciences, Endocrinology, Genetics +17

Disodium salt of 2-[(dihydroxyphosphinyl)difluoromethyl]propenoic acid: an isopolar and isosteric analog of phosphoenolpyruvate

Dennis P. Phillion, Darryl G. Cleary · The Journal of Organic Chemistry · 1992 · 68 citations

Life Sciences, Biochemistry, Chemistry +9

Difluoromethyldiphenylphosphine oxide. A new reagent for conversion of carbonyl compounds to 1,1-difluoroolefins.

M. L. EDWARDS, David M. Stemerick, Esa T. Jarvi et al. · Tetrahedron Letters · 1990 · 64 citations

Natural Sciences, Chemistry, Organic Chemistry +3

Inhibitors of 17α-Hydroxylase/17,20-Lyase (CYPl7): Potential Agents for the Treatment of Prostate Cancer

A. Brodie, Vincent C.O. Njar · Current Pharmaceutical Design · 1999 · 63 citations

Medicine, Endocrinology, Pharmacology +17