Spontaneous and induced plasma-cell neoplasia in a strain of mice

Abstract

ANEOLJS leukeinia has been observed in practically all inlirctl strains ol mice and indeed also i n stock mice; i n a lew strains tlie incidence is high b u t i n most otlicrs 1oiv (a ft:w per cent) .Most often such leukemias have becn of tlie lynipliogenoiis variety in which the leukemic cells arc lymphocytes, lyniplioblasts, or transitional forms between the two;ls-22% :{:{I N less coiiniion is niyelogcnous leukcniia i n wIiicIi the characteristic nialignant cells ha\ (, beeti inore 01-less atypical 1.7. 2 0 . 2 2 , x Since i t is difficult to differentiate Iyniphoblasts f'roln iii)elol)lasts, leukemias showing these forins 01 c d l s have lately olten I)eeti tcriiie(1 merely stem-cell lcukcniias.I n atltlition, a lew instances of nionocytic leukeiiiia h a \ c been reported i n various strains1, 1s and a I'ew cases ol so-called mast-cell leukeniia have been desci-ibed.s~:Is I n otlicr words, most of the Icukerriias theoretically possi1)le in humans have been olJservcc1 i n mice.Plosnin-rcll lrirkeinicr, however, does not appear to have Ixen observed previously, either i n the known inbred strains or in stock niicc.'I'lierefore, the writers feel justified i n submitting a nuntlxr o f cases of plasina-cell leukemia and local plasinocytonias occurring in a strain o f inice (Street). Inyclocytcs, ~~ronl)clocytcs, or Inyeloblasts.'~ h ~A T l < R I A LIncidence crud Si117ii71nZ Time. 411the leu- kemias and plasniocytonias to be reported WTI-C obseriwl i n Street mice.A t that time this strain, i n wliicli tlcvelopnicnt o f spontaneous leukemia has been tlescribctl previously,", Z s was not a piire inbred strain, b u t i t had been F'roiii the FiI)im~r L;rboratorv at the IJni\-ersitv In-~~~~~ ~~ ~~ .