Concepedia

Lack of an association between apolipoprotein E ϵ4 and Alzheimer's disease in elderly nigerians

B. O. Osuntokun, Amrik Sahota, Adesola Ogunniyi, Oye Gureje, Olusegun Baiyewu, A. O. Adeyinka, Steve Oluwole, O.O. Komolafe, Kathleen Hall, Frederick W. Unverzagt,

Annals of Neurology · 1995 · 161 citations · 14 references

DOI

Concepts

MedicineGeneticsNeurologyDementiaGenetic EpidemiologyGeriatricsAlzheimer DiseaseCognitive ImpairmentDementia EpidemiologyDementia GeneticsDementia Risk FactorsAllele FrequencyAlzheimer Disease DementiaAlzheimer Disease EpidemiologyApoe GeneticsApolipoprotein E Genotype RiskApolipoprotein E VariantsElderly PopulationGenetic Epidemiology Of Dementia

Abstract

As part of a community-based study of Alzheimer's Disease (AD) in a Nigerian population aged 65 years and over, we have determined apolipoprotein E (APOE) genotypes on 56 subjects (39 controls and 17 subjects with dementia, including 12 with AD). The epsilon 4 allele of APOE was not associated with AD or dementia in this community-based sample. The epsilon 4 allele frequency was 17.6% in demented patients and 16.7% in AD patients compared with 20.5% in the control subjects. These findings are in marked contrast to the strong association between the epsilon 4 allele and AD in our previously reported study with African Americans.