Fatty Liver and Fibrosis in Glycine N -Methyltransferase Knockout Mice Is Prevented by Nicotinamide

Abstract

The findings of this study indicate that the anomalous accumulation of SAM in GNMT-KO mice can be corrected by NAM treatment leading to the normalization of the expression of many genes involved in fatty acid metabolism, oxidative stress, inflammation, cell proliferation, and apoptosis, as well as reversion of the appearance of the pathologic phenotype.