Chemotherapy · 2009 · 16 citations · 0 references
MedicineOncologyPharmacologyCancer PharmacologyMolecular OncologyMolecular VirologyAntiviral AgentsAntiviral PharmacologyAntiviral PharmacotherapyAntiviral TherapyEnzyme InhibitionAntiviral Drug MechanismsAntiviral TherapeuticsDirect-acting Antiviral AgentsDirect-acting AntiviralsTherapeutic Antiviral Therapy
Pretazettine hydrochloride (PTZ) has been found to inhibit protein synthesis, without being inhibitory to DNA and RNA, in Rauscher leukemic blood cells in mice for at least 6 h after its administration. With comparison to Virazole and cycloheximide, the specific anti-Rauscher virus activity of PTZ has been demonstrated only in acutely-infected NIH/3T3 cells but not in chronically-infected cells. It is not certain that the inhibitory action of PTZ on reverse transcriptase is contributory to its therapeutic activity in leukemic mice.