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Xbp1s-Negative Tumor B Cells and Pre-Plasmablasts Mediate Therapeutic Proteasome Inhibitor Resistance in Multiple Myeloma

Chungyee Leung-Hagesteijn, Natalie Erdmann, Grace W.C. Cheung, Jonathan J. Keats, A. Keith Stewart, Donna Reece, Kim Chan Chung, Rodger E. Tiedemann

Cancer Cell · 2013 · 406 citations · 31 references

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31

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

Marcella A. Calfon, Huiqing Zeng, Fumihiko Urano et al. · Nature · 2002 · 2.9K citations

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Bortezomib or High-Dose Dexamethasone for Relapsed Multiple Myeloma

Paul G. Richardson, Pieter Sonneveld, Michael W. Schuster et al. · New England Journal of Medicine · 2005 · 2.5K citations · Full text

, , +14

Initial genome sequencing and analysis of multiple myeloma

Michael A. Chapman, Michael S. Lawrence, Jonathan J. Keats et al. · Nature · 2011 · 1.4K citations · Full text

, , +15

Plasma cell differentiation requires the transcription factor XBP-1

Andreas Reimold, Neal N. Iwakoshi, John Manis et al. · Nature · 2001 · 1.3K citations

, , +12

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

Esther A. Obeng, Louise Carlson, Delia Gutman et al. · Blood · 2006 · 1.1K citations · Full text

, , +15