ChemMedChem · 2006 · 27 citations · 29 references
MedicineSurgeryOcular Drug DeliveryOphthalmic SurgeryWound HealingGelsHydrogelsIn Situ Ocular GelsOphthalmic GelsVitreoretinal SurgeryVitreous SurgeryHydrogel Biomaterials For OphthalmologyHydrogel FormationOcular HydrogelsScleral Wound RepairVitreous Wound Healing
New lysine-based dendrimers which upon reaction with a poly(ethylene glycol) di-activated ester afford a soft flexible hydrogel that can be used to seal a wound in the sclerotomy. These wounds are made during the common ophthalmic procedure of a vitrectomy. The rheological and swelling properties of the hydrogel can be tuned by either changing the concentration, the type, and/or the generation of the dendrimers.
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