Molecular BioSystems · 2008 · 12 citations · 18 references
Life SciencesBiochemistryMolecular BiologyMass Spectrometric AnalysisProteomicsSpectroscopyMass SpectrometryMass Spectrometry Data AnalysisMass Spectrometry-based ProteomicsPeptide AnalysisPeptide ChemistryPeptide IdentificationAmino AcidsCross-link Peptide IdentificationCross-linked Peptide AnalysisCross-linking Mass SpectrometryCrosslinking Mass SpectrometryIsotopic Labeling Of PeptidesPeptide Mass SpectrometryPeptide-mass Fingerprinting
When isotopically labelled photo-crosslinking amino acids are site-specifically incorporated into proteins, in combination with the corresponding non-labeled analogue, cross-linked tryptic peptides are easily identified in mass spectra via characteristic "doublet" patterns.
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