Chiral ligands: unambiguous assignment of absolute configuration by NMR spectroscopy

Abstract

Two-dimensional rotating-frame nuclear Overhauser enhancement (ROESY) spectra are used to determine the relative configurations at the chiral carbon atoms in the two diastereoisomers of [o-[graphic omittted]d(Ph2PCHMeCHMePPh2)]+PF6– derived from (+) Ph2PCHMeCHMePPh21 and [o-[graphic omittted]dCl]2 of known configurations, and hence to show that the (+) form of 1 has the R,Rconfiguration.