Concepedia

Nox4 Mediates Hypoxia-Stimulated Myofibroblast Differentiation in Nasal Polyp-Derived Fibroblasts

You‐Mi Moon, Hee Joon Kang, Jung-Sun Cho, Il‐Ho Park, Heung-Man Lee

International Archives of Allergy and Immunology · 2012 · 18 citations · 21 references

DOI

Abstract

Hypoxia induces myofibroblast differentiation of NPDF through a signaling pathway involving Nox4-dependent ROS generation and TGF-β(1). Therapies targeting Nox4 may be effective against remodeling of nasal polyps.

References

21

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

Debra F. Higgins, Kuniko Kimura, Wanja M. Bernhardt et al. · Journal of Clinical Investigation · 2007 · 963 citations · Full text

NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts

Ioan C. Cucoranu, Roza E. Clempus, Anna Dikalova et al. · Circulation Research · 2005 · 771 citations · Full text

, , +19

Nox4 NAD(P)H Oxidase Mediates Hypertrophy and Fibronectin Expression in the Diabetic Kidney

Yves Gorin, Karen Block, James Hernandez et al. · Journal of Biological Chemistry · 2005 · 497 citations · Full text

, , +22

Transforming growth factor-β1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells

Anne Sturrock, Barbara C. Cahill, Kimberly G. Norman et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2005 · 395 citations

, , +16

Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature

Manish Mittal, M. Roth, Peter König et al. · Circulation Research · 2007 · 325 citations