Concepedia

Experimental validation of deuterium oxide—mediated antitumoral activity as it relates to apoptosis in murine malignant astrocytoma cells

Takeshi Uemura, Kouzo Moritake, Yasuhiko Akiyama, Yoriyoshi Kimura, Takashi Shingu, Toshiki Yamasaki

Journal of neurosurgery · 2002 · 23 citations · 22 references

DOI

Abstract

The authors found that D2O is cytotoxic to malignant astrocytoma cells. The mechanism of D2O-mediated cytotoxicity involved the induction of apoptosis and cell accumulation during the G2/M phase. This D2O-induced apoptosis is modulated through the caspase activation pathway.

References

22

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

I. Vermes, C. Haanen, H M Steffens-Nakken et al. · Journal of Immunological Methods · 1995 · 5.3K citations · Full text

, , +9

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

Valerie A. Fadok, Dennis R. Voelker, P A Campbell et al. · The Journal of Immunology · 1992 · 3.3K citations

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

Deborah M. Finucane, Ella Bossy‐Wetzel, Nigel J. Waterhouse et al. · Journal of Biological Chemistry · 1999 · 723 citations · Full text

Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo.

Motoo Nagane, Guohua Pan, J J Weddle et al. · PubMed · 2000 · 392 citations

, , +14

Fas Activation of the p38 Mitogen-Activated Protein Kinase Signalling Pathway Requires ICE/CED-3 Family Proteases

Peter Juo, Calvin J. Kuo, Susan E. Reynolds et al. · Molecular and Cellular Biology · 1997 · 284 citations · Full text

, , +20