International Journal of General Medicine · 2013 · 45 citations · 15 references
Enema for the treatment of acute constipation is not without adverse events, especially in the elderly, and should be applied carefully. Perforation, hyperphosphatemia (after Fleet Enema), and sepsis may cause death in up to 4% of cases. Guidelines for the treatment of acute constipation and for enema administration are urgently needed.
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Shawn X. Sun, Marco DiBonaventura, Fanta W. Purayidathil et al. · Digestive Diseases and Sciences · 2011 · 207 citations
Direct medical costs of constipation in the United States.
Barghout, Annamaria Cerulli · PubMed · 2006 · 98 citations
Enema-induced perforation of the rectum in chronically constipated patients
Haim Paran, Gavriel Butnaru, David Neufeld et al. · Diseases of the Colon & Rectum · 1999 · 62 citations