Concepedia

Adrenergic Signaling Regulates Mitochondrial Ca <sup>2+</sup> Uptake Through Pyk2-Dependent Tyrosine Phosphorylation of the Mitochondrial Ca <sup>2+</sup> Uniporter

Jin O‐Uchi, Bong Sook Jhun, Shangcheng Xu, Stephen Hurst, Anna Raffaello, Xiaoyun Liu, Huiliang Zhang, Polina Gross, Jyotsna Mishra, Alina Ainbinder,

Antioxidants and Redox Signaling · 2014 · 87 citations · 58 references

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Abstract

The α1-AR-Pyk2-dependent tyrosine phosphorylation of the MCU regulates mitochondrial Ca2+ entry and apoptosis in cardiac cells.

References

58

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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Joshua M. Baughman, Fabiana Perocchi, Hany S. Girgis et al. · Nature · 2011 · 1.9K citations · Full text

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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Diego De Stefani, Anna Raffaello, Enrico Teardo et al. · Nature · 2011 · 1.9K citations · Full text

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Computational Method to Predict Mitochondrially Imported Proteins and their Targeting Sequences

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PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

Peter Hornbeck, Jon M. Kornhauser, Bin Zhang et al. · Nucleic Acids Research · 2011 · 1.7K citations · Full text