A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

Roy A. Black, Charles T. Rauch, Carl J. Kozlosky, +17

Nature

InflammationMedicineMetalloproteinApoptosisPathology +4

Shock and Tissue Injury Induced by Recombinant Human Cachectin

Kevin J. Tracey, Bruce Beutler, Stephen F. Lowry, +9

Science

Lung InflammationImmunologyCell DeathCellular PhysiologyToxicological Mechanism +16

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

Kevin J. Tracey, Yuman Fong, David Hesse, +5

Nature

Humoral ResponseImmunologySepsisInfection ControlAnti-cachectin/tnf Monoclonal Antibodies +3

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

Bruce Beutler, Ian W. Milsark, Anthony Cerami

Science

Lethal effect of the anti-Fas antibody in mice

Jun Ogasawara, Rie Watanabe‐Fukunaga, Masashi Adachi, +6

Nature

Autoimmune DiseaseImmunologyLethal EffectCell DeathAntibody Screening +5

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

H. R. Michie, Kirk R. Manogue, David R. Spriggs, +6

New England Journal of Medicine

ImmunologyPathologyInflammationBiomarker (Medicine)Translational Medicine +15

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

Klaus Pfeffer, T. Matsuyama, Thomas M. Kündig, +7

Cell

InflammationCytokineImmunologyCell DeathPathology +6

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

Marcia L. Moss, S.-L. Catherine Jin, Marcos E. Milla, +23

Nature

Protein ExpressionMedicineDisintegrin MetalloproteinasePathogenesisNatural Sciences +6

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

Matthias Grell, Eleni Douni, Harald Wajant, +8

Cell

InflammationCytokineTumor Necrosis FactorSignal TransductionTransmembrane Form +8

Processing of tumour necrosis factor-α precursor by metalloproteinases

A. J. H. Gearing, Paul Beckett, Marika Christodoulou, +17

Nature

InflammationMedicineMetalloproteinPathologyCell Death +2