Stereospecific 4-Hydrogen Transfer in the Asymmetric Reduction Using (<i>S</i>S)-3-(<i>p</i>-Tolylsulfinyl)-1,4-dihydropyridines, NADH Model Compounds

Abstract

Abstract In asymmetric reduction of ketones with (SS)-1-benzyl-3-(p-tolylsulfinyl)-1,4-dihydropyridine as a NADH model compound, a stereospecific transfer of the 4-hydrogen was experimentally proved by the use of the 2-methyl congener and the 4-deuterated derivatives.