Plasmodium falciparum: Gene Mutations and Amplification of Dihydrofolate Reductase Genes in Parasites Grown in Vitro in Presence of Pyrimethamine

Human Malaria Parasites in Continuous Culture

William Trager, James B. Jensen · Science · 1976 · 8K citations

Life Sciences, Biology, Infectious Diseases +15

Genetic Analysis of the Human Malaria Parasite <i>Plasmodium falciparum</i>

David Walliker, Isabella A. Quakyi, Thomas E. Wellems et al. · Science · 1987 · 760 citations

Life Sciences, Genetics, Molecular Genetics +17

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

David S. Peterson, David Walliker, Thomas E. Wellems · Proceedings of the National Academy of Sciences · 1988 · 657 citations · Full text

Life Sciences, Genetics, Pharmacology +17

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

Alan F. Cowman, M J Morry, Beverley‐Ann Biggs et al. · Proceedings of the National Academy of Sciences · 1988 · 530 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine.

Yiquan Wu, Laura A. Kirkman, Thomas E. Wellems · Proceedings of the National Academy of Sciences · 1996 · 381 citations

Life Sciences, Genetics, Molecular Biology +15