Concepedia

Extracellular matrix rigidity controls podosome induction in microvascular endothelial cells

Amélie Juin, Emmanuelle Planus, Fabien Guillemot, Petra Horáková, Corinne Albigès‐Rizo, Elisabeth Génot, Jean Rosenbaum, Violaine Moreau, Frédéric Saltel

Biology of the Cell · 2012 · 64 citations · 29 references

DOI

Abstract

Our results show that microvascular endothelial cells are able to form podosomes without specific stimulation. Our data suggest that the major determinant of podosome induction in these cells is substrate rigidity.

References

29

Matrix Elasticity Directs Stem Cell Lineage Specification

Adam J. Engler, Shamik Sen, H. Lee Sweeney et al. · Cell · 2006 · 13.5K citations · Full text

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Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C

Laurent Castéra, Julien Vergniol, Juliette Foucher et al. · Gastroenterology · 2005 · 2.5K citations

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Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

Tony Yeung, Penelope C. Georges, Lisa A. Flanagan et al. · Cell Motility and the Cytoskeleton · 2004 · 2.3K citations

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Podosomes Display Actin Turnover and Dynamic Self-Organization in Osteoclasts Expressing Actin-Green Fluorescent Protein

Olivier Destaing, Frédéric Saltel, Jean-Christophe Géminard et al. · Molecular Biology of the Cell · 2003 · 439 citations · Full text

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Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

Robert W. Tilghman, Catharine Cowan, Justin D. Mih et al. · PLoS ONE · 2010 · 337 citations · Full text