Coating of Human Mesenchymal Cells in 3D Culture with Bioinorganic Nanoparticles Promotes Osteoblastic Differentiation and Gene Transfection

Abstract

Mesenchymal cells are modified in suspension with bio-functionalized calcium phosphate nanoparticles using a scaffold-free cell decoration method. Coated cells remain viable and retain functionality, with cell activity stimulated by the structure and composition of the coating.