A New Sterol from the Soft Coral Lobophytum crassum

Abstract

E-mail: [e-mail] June 1, 2012, Accepted October 2, 2012Key Words : Lobophytum crassum , Anti-Inflammatory, NF- κB, COX-2, iNOSThe nuclear factor kappa B (NF-κB) is the ‘family name’of a group of proteins, all of which possess the Relhomology domain (~300 amino acids in length) at the N-terminus. In mammalian cells, there are five NF-κB sub-units, which are divided into two groups. The first groupconsists of RelA (also known as p65 or NF-κB3), c-Rel andRelB. The second group includes larger proteins p105 andp100, which are processed to produce the mature p50 (alsoknown as NF-κB1) and p52 (also known as NF-κB2)proteins, respectively.