Synthesis of Benzo[b]phenanthridines and Related Naturally Occurring 2-Aryl-1,4-naphthoquinones by Palladium- and Copper-Catalyzed Coupling of Organostannanes with Bromoquinones

Abstract

Syntheses of phenanthroviridone, gilvocarcin BE-12406X2, antibiotic WS 5995B, and a key intermediate for the synthesis of jadomycin are described, based on palladium- and copper-catalyzed coupling reactions of sterically hindered arylstannanes with 2-bromonaphthoquinones.