Atorvastatin Donor Pretreatment Prevents Ischemia/Reperfusion Injury in Renal Transplantation in Rats: Possible Role for Aldose-Reductase Inhibition

Abstract

Our data suggest that downregulation of aldose reductase in renal tissue might underlie the protective effect of donor atorvastatin treatment. Donor pretreatment with a statin or an aldose reductase inhibitor could offer a new treatment strategy to prevent transplantation associated tissue injury.