Science · 1986 · 400 citations · 10 references
Veterinary MedicineInfectious DiseasesMolecular BiologyMolecular VirologyRuminant MedicineVirologyAnimal Infectious DiseasesAnimal VirusesRuminant Infectious DiseasesSwine VirologyVeterinary VirologyAntiviral PeptidesComparative EvaluationExperimental Animal Models Of Viral InfectionFoot And Mouth Disease PreventionFoot-and-mouth Disease In PigsFoot-and-mouth Disease Vaccination
A chemically synthesized peptide consisting essentially of two separate regions (residues 141 to 158 and 200 to 213) of a virus coat protein (VP1) from the O1 Kaufbeuren strain of foot-and-mouth disease virus was prepared free of any carrier protein. It elicited high levels of neutralizing antibody and protected cattle against intradermolingual challenge by inoculation with infectious virus. Comparative evaluation of this peptide with a single-site peptide (residues 141 to 158) in guinea pigs suggests the importance of the VP1 carboxyl terminal residues in enhancing the protective response.
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Cloned Viral Protein Vaccine for Foot-and-Mouth Disease: Responses in Cattle and Swine
Dennis G. Kleid, Daniel G. Yansura, Barbara Small et al. · Science · 1981 · 500 citations