Understanding Intracellular Transport Processes Pertinent to Synthetic Gene Delivery via Stochastic Simulations and Sensitivity Analyses

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Otmane Boussif, Frank Lezoualc’h, Maria Antonietta Zanta et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations · Full text

Engineering, In Vivo Gene Therapy, Several Polycations +20

Size-dependent DNA Mobility in Cytoplasm and Nucleus

Gergely L. Lukács, Peter M. Haggie, Olivier Seksek et al. · Journal of Biological Chemistry · 2000 · 747 citations · Full text

PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles

Swaroop Mishra, Paul Webster, Mark E. Davis · European Journal of Cell Biology · 2004 · 715 citations

Cell-based Drug Delivery, Nanomedicine, Engineering +10

Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer

Delphine Lechardeur, K-J Sohn, Martin Haardt et al. · Gene Therapy · 1999 · 626 citations

Genome Instability, Natural Sciences, Genetics +10

Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery

David V. Schaffer, Nick A. Fidelman, Nily Dan et al. · Biotechnology and Bioengineering · 2000 · 517 citations