Concepedia

Construction of Chiral 1,2-Cycloalkanopyrrolidines from L-Proline Using Ring Closing Metathesis (RCM).

Mitsuhiro Arisawa, Maki Takahashi, Emiko Takezawa, Takenobu Yamaguchi, Yasuhiro Torisawa, Atsushi Nishida, Masako Nakagawa

Chemical and Pharmaceutical Bulletin · 2000 · 53 citations · 0 references

DOI Full text

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Concepts

Natural SciencesChemistryMedicinal ChemistryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsHeterocyclic Medicinal ChemistryOlefin MetathesisOlefin Metathesis CatalysisPyrrolidine SynthesisRing-closing Metathesis

Abstract

An efficient synthetic method for the preparation of optically active pyrroloazocine, pyrroloazepine, quinolizidine, indolizidine using ring closing olefin metathesis (RCM) is described.