Concepedia

Evolved Stereoselective Hydrolases for Broad-Spectrum G-Type Nerve Agent Detoxification

Moshe Goldsmith, Yacov Ashani, Yair Simo, Moshe Ben‐David, Haim Leader, Israel Silman, Joel L. Sussman, Dan S. Tawfik

Chemistry & Biology · 2012 · 95 citations · 30 references

DOI

Concepts

References

30

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

Michal Harel, Amir Aharoni, Leonid Gaidukov et al. · Nature Structural & Molecular Biology · 2004 · 640 citations

, , +12

Structure−Reactivity Studies of Serum Paraoxonase PON1 Suggest that Its Native Activity Is Lactonase

Olga Khersonsky, Dan S. Tawfik · Biochemistry · 2005 · 452 citations

, , +12

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization

Amir Aharoni, Leonid Gaidukov, Shai Yagur et al. · Proceedings of the National Academy of Sciences · 2003 · 288 citations · Full text

, , +17

Intense Neutral Drifts Yield Robust and Evolvable Consensus Proteins

Shimon Bershtein, Korina Goldin, Dan S. Tawfik · Journal of Molecular Biology · 2008 · 263 citations

, , +4

Progress in Medical Defense Against Nerve Agents

Michael A. Dunn · JAMA · 1989 · 257 citations

, , +8