Effect of N‐(<i>p</i>‐coumaroyl)serotonin and N‐feruloylserotonin, major anti‐atherogenic polyphenols in safflower seed, on vasodilation, proliferation and migration of vascular smooth muscle cells

Abstract

These results indicated a possible vascular effect of CS/FS to inhibit the activation of VSMCs by blocking the increase of [Ca(2+) ](i) and/or blocking PDGF signaling. These may explain a part of anti-atherogenic mechanism that underlies their ability to improve vascular distensibility and to inhibit aortic hyperplasia.