Concepedia

Efficient Synthesis of 2,4-Disubstituted Thiazoles Under Grinding

Majid M. Heravı, Nargess Poormohammad, Yahia Sh. Beheshtiha, Bita Baghernejad

Synthetic Communications · 2011 · 19 citations · 11 references

DOI

Concepts

Abstract

Abstract A simple and convenient protocol is described for the preparation of 2,4-disubstituted thiazoles via a condensation reaction of α -halo carbonyl compounds with thiourea or thioacetamide at room temperature, under grinding, in good yields.

References

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Phenethylthiazolethiourea (PETT) Compounds, a New Class of HIV-1 Reverse Transcriptase Inhibitors. 1. Synthesis and Basic Structure-Activity Relationship Studies of PETT Analogs

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