Concepedia

Synthesis of a 2,3‘;6‘,3‘ ‘-Terpyridine Scaffold as an α-Helix Mimetic

Jessica Davis, Vy Anh Truong, Andrew D. Hamilton

Organic Letters · 2005 · 80 citations · 14 references

DOI

Abstract

[reaction: see text] A terpyridine scaffold has been designed as an alpha-helix mimetic. A facile synthesis of the ortho-functionalized 2,3'-oligopyridine has been accomplished using sequential Bohlmann-Rahtz heteroannulation reactions.

References

14

Structure of Bcl-x <sub>L</sub> -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

Michael Sattler, Heng Liang, David G. Nettesheim et al. · Science · 1997 · 1.5K citations

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Toward Proteomimetics:  Terphenyl Derivatives as Structural and Functional Mimics of Extended Regions of an α-Helix

Brendan P. Orner, Justin T. Ernst, Andrew D. Hamilton · Journal of the American Chemical Society · 2001 · 312 citations

, , +15

Development of a Potent Bcl-x<sub>L</sub>Antagonist Based on α-Helix Mimicry

Olaf Kutzki, Hyung Soon Park, Justin T. Ernst et al. · Journal of the American Chemical Society · 2002 · 247 citations

Design of a Protein Surface Antagonist Based on α-Helix Mimicry: Inhibition of gp41 Assembly and Viral Fusion We thank the National Institutes of Health for support of this work and the Deutsche Forschungsgemeinschaft (DFG) for a research fellowship to O.K.

Justin T. Ernst, Olaf Kutzki, Asim K. Debnath et al. · Angewandte Chemie International Edition · 2002 · 167 citations

, , +22

A new one-pot three-component condensation reaction for the synthesis of 2,3,4,6-tetrasubstituted pyridines

Mark C. Bagley, James W. Dale, Justin Bower · Chemical Communications · 2002 · 122 citations

, , +6