Inotropic Response to Digoxin and Dopamine in Patients with Severe Sepsis, Cardiac Failure, and Systemic Hypoperfusion

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

Michael R. Bristow, Robert Ginsburg, Wayne Minobe et al. · New England Journal of Medicine · 1982 · 2.3K citations

Medicine, Cardiology, Physiology +14

Profound but Reversible Myocardial Depression in Patients with Septic Shock

Margaret M. Parker · Annals of Internal Medicine · 1984 · 1.6K citations

Medicine, Cardiology, Critical Care Cardiology +10

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

Roger C. Bone, Charles J. Fisher, Terry P. Clemmer et al. · New England Journal of Medicine · 1987 · 1.4K citations

Medicine, Pharmacology, Pharmacotherapy +16

A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.

Joseph E. Parrillo, Cynthia Burch, James H. Shelhamer et al. · Journal of Clinical Investigation · 1985 · 621 citations · Full text

Veterinary Medicine, Cardiology, Physiology +12

Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response.

Michael B. Fowler, J Laser, G L Hopkins et al. · Circulation · 1986 · 565 citations

Medicine, Cardiology, Pharmacology +14