Genomic analysis of the response of mouse models to high-fat feeding shows a major role of nuclear receptors in the simultaneous regulation of lipid and inflammatory genes

Gene Ontology: tool for the unification of biology

Michael Ashburner, Catherine A. Ball, Judith A. Blake et al. · Nature Genetics · 2000 · 44.6K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +9

Identification of a Nuclear Receptor for Bile Acids

Makoto Makishima, Arthur Y. Okamoto, Joyce J. Repa et al. · Science · 1999 · 2.7K citations

Life Sciences, Genetics, Molecular Biology +17

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

Sunny H. Zhang, Robert L. Reddick, Jorge A. Piedrahita et al. · Science · 1992 · 2.2K citations

Life Sciences, Cardiology, Genetics +17

Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

Knut Erik Berge, Hui Tian, Gregory A. Graf et al. · Science · 2000 · 1.6K citations

Life Sciences, Genetics, Molecular Genetics +17

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

Yong‐Xu Wang, Chih‐Hao Lee, Sambath Tiep et al. · Cell · 2003 · 1.3K citations · Full text

Life Sciences, Biochemistry, Physiology +12