DISAPPEARANCE OF CARCINOMATOUS ULCERATION OF BLADDER FOLLOWING URETEROSIGMOIDOSTOMY

Abstract

It is my purpose to report clinical disappearance of carcinomatous ulceration of bladder following diversion of urinary stream and to point out possible biologic significance of this phenomenon in connection with cause of certain tumors of bladder. These observations are based on repeated cystoscopic studies confirmed by preoperative biopsy and by subsequent gross and microscopic examination of excised bladder by competent pathologists.1 The obvious inference that these tumors were caused by a carcinogenic urinary ingredient is thought provoking and involves a consideration of closely related subject of chemical carcinogenesis, which may be defined as the production of malignant, transplantable, metastasizing new growths in laboratory animals or human beings by action of cancerproducing chemicals introduced into body, intentionally or inadvertently, by ingestion, inhalation, injection or cutaneous application (Davis2). Although having received but scant mention in other than special journals,