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Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function

DOIFull Paper Access

116

Citations

31

References

2008

Year

Harald Staiger, Fausto Machicao, Silke Schäfer, Kerstin Kirchhoff, Kοnstantinos Kantartzis, Martina Guthoff, Günther Silbernagel, Norbert Stefan, Hans‐Ulrich Häring, Andreas Fritsche
PLoS ONE

Abstract

In conclusion, common genetic variation within MTNR1B determines glucose-stimulated insulin secretion and plasma glucose concentrations. Their impact on beta-cell function might represent the prevailing pathomechanism how MTNR1B variants increase the type 2 diabetes risk.

References

YearCitations

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